TOP GUIDELINES OF PKRRATING

3B). R526 within the loop among αJ and αI anchors the C-terminal part of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the leading chain carbonyl of R413. The tip from the activation phase is stabilized by a hydrogen bond involving Y454 and E480 from αF. within the